The increasing global burden of obesity and its metabolic complications necessitates a detailed understanding of specific metabolic phenotypes. This study investigates the 25-year trends in the prevalence of eight metabolic phenotypes that are categorized by body mass index (BMI) and metabolic health status, among Iranian adults from 2000 to 2025.

Self-monitoring of blood glucose (SMBG) is a part of diabetes management. Numerous investigations have demonstrated inadequate adherence to SMBG. We investigated the level of adherence to SMBG in diabetic type 2 patients treated with insulin or sulfonylureas/meglitinide and the population attributable fraction of associated factors to SMBG in Iran.

Antidiabetic drugs differ in their effects on body composition, which may influence metabolic and functional outcomes. This systematic review and network meta-analysis aimed to quantify and compare effects of major antidiabetic drugs on key body composition parameters.

To evaluate the staging performance of positron emission tomography/magnetic resonance imaging (PET/MRI) for confirmed esophageal cancer based on the TNM classification system as well as compare it to other alternative modalities (e.g., endoscopic ultrasonography (EUS), computed tomography (CT), MRI, and PET/CT) in a full head-to-head manner.

Although no pharmacological treatments have received regulatory approval for borderline personality disorder (BPD), antipsychotic medications—particularly haloperidol, olanzapine, and risperidone—are frequently prescribed off-label in clinical practice. This study aims to quantitatively compare the efficacy of these three agents in the management of BPD. Moreover, considering the heterogeneous presentations of BPD among patients, the efficacy of these agents is also quantitatively compared in controlling individual symptom domains, including depression, anxiety, interpersonal challenges, cognitive impairment, impulsivity, and hostility. Due to the lack of head-to-head trials, indirect comparisons were conducted through a meta-analysis of effect sizes derived from open-label studies.

Many studies have reported the aberrant expression of lncRNAs and indicated their role in cancer progression and drug resistance across various cancers. In this study, we aimed to evaluate the effect of LINC00162 lncRNA on the chemosensitivity of thyroid cancer cells, both individually and in combination with sorafenib, on various biological processes. In this regard, we conducted our experiments in several groups: (1) LINC00162 siRNA-transfected cells, (2) Sorafenib-treated cells, (3) Cells that received both siRNA transfection and sorafenib treatment (4) Control group. MTT assay results revealed that siRNA-mediated silencing of LINC00162 reduced the viability of the B-CPAP thyroid cancer cells and increased the sensitivity of these cells to sorafenib by reducing its IC50.

To investigate the efficacy of Sarcomeal® sachet, as a protein supplement, plus vitamin D3 on muscle parameters, metabolic factors, and quality of life (QoL) in individuals with diabetes and sarcopenia.

Diabetes mellitus, particularly Type 2 diabetes (T2D), represents a significant global health challenge, with its prevalence steadily rising over the past few decades. This study was conducted with the aim of estimating the economic burden of T2D in Iran.

While only a few postmenopausal women exhibit biochemical signs of hypovitaminosis D, it has been shown that vitamin D insufficiency has detrimental effects on the overall skeleton mineralization, bone turnover rate, and may be a significant risk factor for osteoporosis and fracture. We evaluated the concurrent effect of Vitamin D levels and biochemical markers of bone turnover on bone health of postmenopausal women.

Improving the quality of diet is known as one of the practical ways to reduce cardio-metabolic risk factors (CMRFs). The carbohydrate quality index (CQI) is a relatively new index to evaluate diet quality. It is calculated based on the ratio of solid carbohydrates to total carbohydrates, dietary fibre intake, glycemic index and the ratio of whole grains to total grains. This systematic review and meta-analysis was designed to investigate the association between dietary CQI and CMRFs.